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Enko Acquires DNA-Encoded Libraries from X-Chem.

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Vincent

MANews-(C)2009-2022

US-based crop health company Enko has acquired proprietary DNA-encoded libraries and technology enablement from drug discovery service company X-Chem, the company said.

Enko said it is the first company to internalize this technology for agricultural applications.

The libraries will help speed the discovery and development of safe, sustainable crop protection solutions urgently needed by farmers.

DNA-encoded libraries are a proven tool to kickstart pharmaceutical drug discovery projects because of the efficiency of screening large, diverse chemical spaces.

Enko has pioneered applying this approach to tackle agriculture challenges.

This acquisition is a significant advancement for Enko's Enkompass platform, which combines DNA-encoded library screening with machine learning and structure-based design to find novel chemistry and new modes of action to control crop pests and diseases.

Enko's targeted discovery method uncovers promising chemical starting points in months, compared to the years it takes for traditional R and D approaches.

Pairing DNA-encoded library screening with machine learning allows Enko to tap into novel chemical spaces, which is critical for overcoming widespread pest resistance.

With these new libraries, each experiment will produce molecular starting points and training data for machine learning models that increase efficiency of hit generation and lead optimization.

To discover safe and effective new modes of action for pests, Enko can both screen billions of molecules within its DNA-encoded libraries and use artificial intelligence and machine learning to create more effective ways of finding and selecting the right treatments for the right targets, faster than anyone had ever imagined to be possible.

This technology acquisition follows a year in which Enko partnered with three of the largest agricultural companies in the world Bayer, Syngenta and Nufarm.

Enko has had a very strong success rate...

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