The effect of green tea on opposing toxicity of acrylamide on kidney function

Date03 October 2016
Pages353-362
Published date03 October 2016
DOIhttps://doi.org/10.1108/WJSTSD-01-2016-0010
AuthorNahlaa Khalifa,Thanaa Abdel Fattah El-Kholy,Ahmed Al-Ghamdi
Subject MatterPublic policy & environmental management,Environmental technology & innovation
The effect of green tea on
opposing toxicity of acrylamide
on kidney function
Nahlaa Khalifa
Department of Clinical Nutrition, Faculty of Applied Medical Sciences,
King Abdul Aziz University, Jeddah, Saudi Arabia
Thanaa Abdel Fattah El-Kholy
Alazhar University, Cairo, Egypt, and
Ahmed Al-Ghamdi
Department of Applied Medical Sciences, King Abdulaziz University,
Jeddah, Saudi Arabia
Abstract
Purpose The purpose of this paper is to investigate the effects of green tea extract on kidney
function tests, in male rats that received different doses of acrylamide (AA).
Design/methodology/approach Animals were dispensed at random to one of the following
treatments: group 1 served as control, whereas groups 2, 3 received seven, 14 mg/100 g B.W/day of AA,
respectively, in drinking water for 15 and 30 days. Group 4 received green tea 1.5 percent concentration
and groups 5, 6 received seven, 14 mg/100g B.W/day in a mixture with green tea for 15 and 30 days.
Findings Serum urea and creatinine significantly increase with AA. However, Total protein,
albumin and A/G ratio showed significant drop in all treated groups when compared with control.
Supplementation of rats with antioxidant (green tea) enhanced the general health condition, reduced
the severity of genotoxic effect and the alteration in blood and serum parameters produced by AA.
Practical implications The authors suggest that green tea may deliver a cushion for long
therapeutic option against toxins-induced nephrotoxicity without damaging side effects.
Originality/value The study uses green tea as a natural antioxidant source. Epigallocatechin-3
gallate is the most plentiful catechin preserved in green tea and a high source of flavonoids. Flavonoids
are a group of phenolic products of plant metabolism with high antioxidant properties to reduce
nephrotoxicity without side effects.
Keywords Urea, Acrylamide, Green tea, Albumin, Creatinine, Globulin
Paper type Research paper
Introduction
Acrylamide (AA) (2-propenamide) monomer might constitute in some foodstuffs
prepared at elevatedtemperatures (Surdyk et al., 2004).The highest concentrationsof AA
have been recognized in grain-based foods, which are cooked at high temperatures such
as baking, frying or grilling(Tareke et al., 2002). AA is assumed to produce in foodstuffs
mainly from the reaction of asparagines amino acid with some carbohydrates like
glucose (Taubert et al., 2004). AA is found to have important binding power to kidney,
liver, erythrocyte and brain. After absorption glutathione-S-transferase (GST),
conjugated to N-acetyl-S- (3-amino-3-oxopropyl) cysteine (Sumner et al., 1997). Based
on the international agency for research on cancer (IARC, 1994), AA is considered as a
group 2A carcinogen. Calleman et al. (1990) revealed that AA toxic effect production,
could be elucidatedby its metabolism into glycidamide (2E1)through the P450 (CYP450)
cytochrome route to give 2E1, forming a DNA-reactive epoxide. Johnson et al. (1986)
World Journal of Science,
Technology and Sustainable
Development
Vol. 13 No. 4, 2016
pp. 353-362
©Emerald Group Publis hing Limited
2042-5945
DOI10.1108/WJSTSD-01-2016-0010
The current issue and full text archive of this journal is available on Emerald Insight at:
www.emeraldinsight.com/2042-5945.htm
353
The effect of
green tea

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