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Universite de Liege : Psoriasis treatment not effective for severe asthma.

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ENPNewswire-November 1, 2021--Universite de Liege : Psoriasis treatment not effective for severe asthma

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Release date- 29102021 - Risankizumab, a treatment indicated for psoriasis and Crohn's disease, has not been shown to be effective in severe asthma.

A study published this week in The New England Journal of Medicine shows, on the contrary, that this biotherapy worsens symptoms and decreases breath performance in severe asthma.

The international study led by British, Canadian and Belgian researchers involved 214 patients, 105 of whom were randomised to receive an injection of risankizumab every 4 weeks for 24 weeks, and 109 of whom received a placebo.

The researchers measured time to first worsening as determined by increase in symptoms, worsening of breathing tests, increased use of inhalers and need for steroid tablets for exacerbation. The mean time to first worsening was 40 days for patients treated with risankizumab, compared with 86 days for patients treated with placebo.

Risankizumab is a monoclonal antibody known to inhibit Interleukin-23 (IL-23), a cytokine suspected of playing a role in airway inflammation. Based on previous data, IL-23 was known to have the potential to promote both eosinophilia and tissue neutrophilia, and thus to be a key cytokine in severe asthma, which is known to combine both types of granulocytic inflammation in the airways. The researchers hypothesised that IL-23 is a key cytokine in severe asthma, which is known to combine the two types of granulocytic inflammation in the airways, given the proximity of IL-23's mechanisms of action in triggering psoriasis and Crohn's disease, diseases in which risankizumab has good therapeutic results. However, in the case of severe asthma, the results show the exact opposite effect.

Dr Renaud Louis, professor at the ULiege Faculty of Medicine and head of the Pneumology...

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